Effect of DL-glyceraldehyde on mouse neuroblastoma cells in culture.

Neuroblastoma cells had a much higher rate of glycolysis than the Chinese hamster ovary Kl cells, although the former cell type had a longer doubling time (24 hr) than did the latter (12 hr). DL-Glyceraldehyde inhibited the glycolysis in both cell types to the same extent, but it reduced the growth of neuroblastoma cells more markedly than that of Chinese hamster ovary Kl cells. These data indicated that glycolysis may be more critical for the growth of neuroblastoma cells than for the Chinese hamster ovary Kl. In our experimental conditions the higher glycolysis rate did not correlate with the faster growth rate of cells in culture.